Collagen Stimulators

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Unlike dermal fillers which are aimed at mechanically filling wrinkles, folds and skin depressions, tissue stimulators are injectable products which cause a biological reaction in the tissue, upon injection, and thus stimulate the cells to produce new collagen growth. These products are therefore aimed at being sculpting or natural volumizing agents, rather than simply skin fillers or line plumpers.

What it is

Collagen Stimulators are injections that induce the production of new collagen to restore tightness to saggy skin and add volume to hollow areas of the face. The most common areas to treat are the cheeks, around the mouth, the jowls and under the eyes.

What They Can Do


Collagen stimulating injections induce renewal of facial collagen fibers to tone and lift problem facial areas. Over time, these injections provide a significant increase in skin volume and tightness.

Key Benefits

Collagen Stimulator's restore and enhance and will not drastically change your appearance. The results are long lasting up to 3 years when following the initial treatment plan.

Collagen stimulators are best used for a total facial rejuvenation and volume restoration. It can improve volume in areas of skin depressions and creases such as nasolabial folds and marionette lines, replace volume and improve contours in the cheeks and temples and can also be used for large areas of volume loss (lipoatrophy). 

​Solutions for


  • Sagging in the Cheekbone

  • Jawline Support

  • Crepey Tissue

  • Facial Framework Support

  • Volume Loss​

Botox Products

  • Sculptra

  • Radiesse

  • Botox


  • Collagen Stimulators are injected along the areas of facial weakness.

  • During the treatment the solution will be injected into the areas of concern – either with a needle or a blunt microcannula. 

  • The average amount for an initial treatment is 2-3 vials of collagen stimulator.

  • Topical anesthesia will be applied.

  • 3-4 treatments needed. Treatments are 6-8 weeks apart.



Collagen stimulators typically start at $900 each. The general rule of thumb for collagen stimulators is one vial per decade of life. So if you’re in your 40’s, you will most likely need 4 vials. There are exceptions to this rule depending upon volume loss.

Common Side Effects 

  • bruising

  • redness

  • swelling

  • pain at the site of injection

  • infection


Early complications, occurring within days of the procedure, can be divided into non-hypersensitivity and hypersensitivity reactions. The non-hypersensitive reactions include injection site reactions, discoloration, maldistribution, infection, skin necrosis, and the very rare but dreaded risk of vision loss, whereas the hypersensitivity reactions present usually as delayed type IV reactions, but can also rarely present as an immediate type I reaction.


Late complications, occurring within weeks to even years after injection, include granuloma formation, foreign body reactions, and infection secondary to atypical mycobacteria or biofilms. This review will give a detailed overview of the complications secondary to cutaneous collagen injections.

Recovery Expectations

Immediately following the injections, you may experience some redness, slight stinging, minor swelling, or bruising in the treatment area. Tiny scabs may also form at the injection sites. These symptoms typically disappear within two to three days. Bandaging is not necessary and most patients are able to resume normal activities immediately following treatment.

Long Term Results

Results vary from person from person, but in recent studies, Collagen Stimulators can maintain results in the face for on average 18-24 months from the end of the treatment sessions.